Safety Evaluation
Primary irritation test (PIT)
Evaluates irritation CIT and RIPT through a single patch of the test product
Test period 1week
Number of subjects 30 or more
Cumulative irritation test (CIT)
Evaluates whether there is irritation through cumulative patches of the test product
Test period 3week
(5 days, 14 days or 21 days)
Number of subjects 30 or more
Repeated insult patch test (RIPT)
Evaluates the possibility of inducing allergy through cumulative patches of test product over three weeks
Test period 6week
Number of subjects 50 or more
In vivo test for the induction of comedones (face)
Evaluates the suitability of use for acne-prone skin through a visual evaluation by experts after the test product is used on the face
Test period 4week
(adjustable depending on test design)
Number of subjects 20 or more
In vivo test for induction of comedones (back)
In accordance with the Ministry of Food and Drug Safety’s “Guidelines for Testing Methods for the Verification of Cosmetic Labeling and Advertising”
Acne-prone skin with a closed patch on the back
Test period 4week
(adjustable depending on test design)
Number of subjects 20 or more
In vivo test for usability evaluation
Evaluates usability through a survey after the product has been used for a certain period
Test period 4week
(adjustable depending on test design)
Number of subjects 20 or more
In vivo test for eye irritation
Evaluates eye irritation through the ophthalmic evaluation indicators of ophthalmologists after the test product is used
Test period 2week
(adjustable depending on test design)
Number of subjects 20 or more